Comparison of an Enzyme Immunoassay and a High Performance Liquid Chromatographic Method for Quantitation of Quinidine in Serum

Abstract
The need to monitor serum or plasma levels of quinidine in the treatment of cardiac arrhythmia is well documented [1-3] Quinidine has been assayed by fluorometry [4, 5], chromatographic methods [6, 7, 9], and, most recently, an enzyme immunoassay technique (EMIT). We have compared the enzyme immunoassay method with a reverse-phase high performance liquid chromatographic method [7, 9]