THE RELATION OF MENSTRUATION TO THE PERMEABILITY OF THE SKIN CAPILLARIES AND THE AUTONOMIC TONUS OF THE SKIN VESSELS

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Abstract
In view of the intimate relation of the capillary permeability to autonomic and endocrine disturbances and the peculiar effect apparent in the reactivity of the skin, we have carried out a series of blister observations on a group of normal young women. The technic has been that described in the first article.1 That there is a change in capillary permeability preceding and during menstruation has been determined by Heilig and Hoff2 and by Benda,3 who have worked with dye injections and have found that the meninges becomes more permeable. Heilig and Hoff found in animal experimentation that thyroid extract and ovarian extract make the meninges more permeable.4 In the accompanying table we have tabulated the blister time and the permeability ratio in relation to the menstrual time. In the first part (A), menstrual and premenstrual observations show that in the premenstrual period the blister time is shortened (the skin is

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