Prenatal growth in the cynomolgus and rhesus macaque (Macaca fascicularis and Macaca mulatta): A comparison by ultrasonography
- 1 January 1988
- journal article
- research article
- Published by Wiley in American Journal of Primatology
- Vol. 15 (4) , 309-323
- https://doi.org/10.1002/ajp.1350150405
Abstract
The rhesus monkey has played an important role in the history of reproductive research. Because of limitations on the exportation and availability of this species, several other species of nonhuman primates have been considered as alternate models. Among them is the crab-eating, or cynomolgus, macaque (Macaca fascicularis), which displays similarities in developmental, reproductive, and physiological parameters. The use of both species of macaques for pregnancy-related studies necessitates the assessment of differences in growth and development through gestation. Observations during the embryonic and fetal periods in both species have been compared with diagnostic ultrasound. Results indicate no significant differences in size during the embryonic and early fetal periods, but a greater acceleration of growth in the rhesus begins at approximately 100-110 gestational days (GD). Analysis of embryonic and fetal heart rates indicate no differences between the two species. Normal predictive values for a variety of growth parameters including gestational sac, greatest length, biparietal diameter, and femur length have been calculated by multiple regression analysis. These charts have proven useful for confirming the gestational age after timed matings and for predicting the age of animals for which the conception date is not known.Keywords
This publication has 15 references indexed in Scilit:
- Characterization of a monoclonal antibody which detects luteinizing hormone from diverse mammalian speciesDomestic Animal Endocrinology, 1987
- Monitoring Ovulation and Implantation in the Cynomolgus Macaque (Macaca fascicularis) Through Evaluations of Urinary Estrone Conjugates and Progesterone Metabolites: A Technique for the Routine Evaluation of Reproductive ParametersJournal of Medical Primatology, 1986
- Evaluation of Bendectin embryotoxicity in nonhuman primates: I. Ventricular septal defects in prenatal macaques and baboonTeratology, 1985
- Development of mouse embryos in hanging drop cultureThe Anatomical Record, 1985
- Estimating fetal age: computer-assisted analysis of multiple fetal growth parameters.Radiology, 1984
- Surrogate Embryo Transfer Combined With Estrogen-Progesterone Therapy in MonkeysPublished by American Medical Association (AMA) ,1983
- Computer assisted analysis of fetal age in the third trimester using multiple fetal growth parametersJournal of Clinical Ultrasound, 1983
- Use of a radioreceptorassay (RRA) for human luteinizing hormone/chorionic gonadotropin (hLH/CG) for detection of early pregnancy and estimation of time of ovulation in macaquesAmerican Journal of Primatology, 1983
- A standardized plane for biparietal diameter measurement.Journal of Ultrasound in Medicine, 1982
- The use of ultrasound in the assessment of normal fetal growth: A reviewJournal of Clinical Ultrasound, 1981