Acid-catalysed hydrolysis of prostacyclin: origin of the unused lability
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 3,p. 129-130
- https://doi.org/10.1039/c39790000129
Abstract
The extra lability (89 ×) of prostacyclin towards acid-catalysed hydrolysis of its vinyl ether functional group in aqueous solution at 25 °C is traced to the carboxylic acid residue of this molecule operating in its ionized form, either as an electrostatic catalyst or, upon prior protonation, as an intramolecular general acid catalyst.This publication has 0 references indexed in Scilit: