Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini
- 7 May 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 170 (1) , 64-68
- https://doi.org/10.1016/0014-5793(84)81369-1
Abstract
The combination of the ionophore A23187 and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates amylase secretion from rabbit pancreatic acini up to a level equal to, or slightly higher than when carbachol is used as stimulant. Each of the two compounds alone gives only a minor stimulation. This synergistic effect of A23187 and TPA supports a role of protein kinase C in pancreatic enzyme secretion.Keywords
This publication has 27 references indexed in Scilit:
- Insulin secretion: Combined effects of phorbol ester and A23187Biochemical and Biophysical Research Communications, 1983
- Aldosterone secretion: Effect of phorbol ester and A23187Biochemical and Biophysical Research Communications, 1983
- Phospholipid-sensitive calcium-dependent protein kinase and its endogenous substrate proteins in rat pancreatic acinar cellsLife Sciences, 1983
- Synergistic functions of phorbol ester and calcium in serotonin release from human plateletsBiochemical and Biophysical Research Communications, 1983
- Stimulus-excitation coupling in plasma membranes of pancreatic acinar cellsBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1982
- Increased intracellular cyclic GMP does not correlate with protein discharge from pancreatic acinar cellsNature, 1979
- Inositol phospholipids and cell surface receptor functionBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1975
- Pancreatic acinar cells: Use of a Ca++ ionophore to separate enzyme release from the earlier steps in stimulus-secretion couplingBiochemical and Biophysical Research Communications, 1974
- Acetylcholine causes a net decrease in phosphatidylinositol and a net increase in phosphatidic acid in mouse pancreasBiochemical and Biophysical Research Communications, 1974
- Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slicesBiochimica et Biophysica Acta, 1954