Effect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin
- 1 March 1987
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 72 (3) , 383-385
- https://doi.org/10.1042/cs0720383
Abstract
1. Dietary fat influences many aspects of immune function. Escherichia coli endotoxin is a potent stimulator of interleukin 1 production from macrophages. 2. The present study examines the effect of feeding with fat diets rich (corn oil) and poor (coconut oil) in linoleate at high and low concentrations on responses to endotoxin. 3. Spleen phosphatidylcholine linoleate contents were higher in the corn oil than in the coconut oil group and arachidonate concentrations were highest in the group fed a high concentration of corn oil. 4. Coconut oil completely abolished the responses to endotoxin. 5. The inhibitory effects of coconut oil could largely be due to reduced prostaglandin and leukotriene synthesis.This publication has 3 references indexed in Scilit:
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- Effect of ibuprofen on fever and metabolic changes induced by continuous infusion of leukocytic pyrogen (interleukin 1) or endotoxinInfection and Immunity, 1983
- The use of 1,6-diphenylhexatriene to detect lipids on thin-layer chromatogramsAnalytical Biochemistry, 1980