A LHASA analysis of taxol
- 1 January 1994
- journal article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 113 (5) , 297-303
- https://doi.org/10.1002/recl.19941130507
Abstract
A retrosynthetic analysis using the computer program LHASA of the promising antitumor agent taxol (1) is described, which resulted in a synthetic route with the following key steps: an intramolecular Diels‐Alder reaction generating the AB rings, and the coupling reactions of the required diene and dienophile with a CD‐ring fragment. The feasibility of the route is studied by comparing the LHASA analysis with related chemistry from the literature. Finally, a critical discussion about the usability of the LHASA program for the planning of complex organic molecules is given.]Funding Information
- Dutch National Expertise Center CAOS/CAMM
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