Modeling AIDS in a Mouse
- 15 September 1996
- journal article
- review article
- Published by Taylor & Francis in Hospital Practice
- Vol. 31 (9) , 41-60
- https://doi.org/10.1080/21548331.1996.11443344
Abstract
Mice that are lacking their own lymphocytes are given a human immune system, which then is infected with HIV Such models are proving themselves in studies of immunization techniques. They also yield insights into HIV, including its capacity for infecting particular cell types and its so-called accessory genes. The models may even help in establishing precisely how HIV kills host CD4 T cells.Keywords
This publication has 9 references indexed in Scilit:
- Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 InfectionCell, 1996
- CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1Science, 1996
- Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding siteAIDS, 1995
- Cloned human CD8+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism.The Journal of Immunology, 1994
- Rapid Loss of CD4 + T Cells in Human-PBL-SCID Mice by Noncytopathic HIV IsolatesScience, 1993
- Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160.Proceedings of the National Academy of Sciences, 1993
- Pathogenesis of human immunodeficiency virus infection.Microbiological Reviews, 1993
- The SCID-hu Mouse: A Small Animal Model for HIV Infection and PathogenesisAnnual Review of Immunology, 1991
- Human Immunodeficiency Virus Infection of Human-PBL-SCID MiceScience, 1991