Haloperidol-Induced Plasticity of Axon Terminals in Rat Substantia Nigra

2 September 1983

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 221 (4614) , 969-971
https://doi.org/10.1126/science.6879197

Abstract

An electron micrographic morphometric analysis of nerve endings in substantia nigra of rats repeatedly treated with haloperidol was performed. Although most parameters showed no difference, drug-treated animals exhibited a significant shift in the distribution of relative numbers of axon terminals, suggesting neuroleptic-induced axon-collateral sprouting.

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