MATERNAL AND FETAL PLASMA BUPIVACAINE CONCENTRATIONS IN LABOR WITH SEGMENTAL EPIDURAL ANALGESIA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 67  (5) , 190-194
Abstract
Maternal and fetal plasma bupivacaine concentrations were assayed following segmental epidural analgesia during the 1st stage of 14 normal labors. Analgesia was accomplished with 20 mg of 0.5% bupivacaine. Mothers (10) received only 1 dose and 4 mothers 2 doses. The maternal and fetal plasma bupivacaine levels remained very low and the fetomaternal ratios were about 1:4 during the labor. At delivery, the feto-maternal ratio increased, showing that the decline of bupivacaine concentrations is slower in fetal than in maternal plasma.

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