Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients

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Abstract
A double-blind, randomized, group comparative study was performed in hypogonadal male patients in order to compare the effects on sexual activity and mental state of testosterone undecanoate (TU) and mesterolone (M). The TU-treated group contained 12 patients, and the M-treated group contained 14 patients. The variables of sexual activity and of mental state were scored and evaluated statistically by means of the nonparametric randomization test for 2 independent groups. TU induced a marked improvement of the sexual activity and of the mental state. After 4 weeks of treatment the effects were significantly better than in the M-treated group: libido (p < 0.001), erections (p < 0.01), ejaculations (p < 0.05) and mental state (p < 0.001).