Genomic and Proteomic Analysis of Mammary Tumors Arising in Transgenic Mice
- 12 November 2005
- journal article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 4 (6) , 2088-2098
- https://doi.org/10.1021/pr050214l
Abstract
Transforming growth factor-β (TGF-β) is the prototype of a large family of signaling molecules. TGF-β signaling profoundly influences tumor development as demonstrated in several engineered mouse models. The present study was designed to identify differences by cDNA microarray and MALDI-TOF MS analyses in mammary carcinomas with and without TGF-β signaling. The results demonstrate a significant potential for combination of profiling technologies to further understand the molecular mechanisms of breast cancer. Keywords: microarray • MALDI-TOF mass spectrometry • mammary tumor • transgenic mouseKeywords
This publication has 26 references indexed in Scilit:
- Prediction of Docetaxel Response in Human Breast Cancer by Gene Expression ProfilingJournal of Clinical Oncology, 2005
- Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian CellsMolecular & Cellular Proteomics, 2004
- Regulation of cytoskeletal dynamics by actin-monomer-binding proteinsTrends in Cell Biology, 2004
- Transforming Growth Factor-β1 Specifically Induce Proteins Involved in the Myofibroblast Contractile ApparatusMolecular & Cellular Proteomics, 2004
- Tumor Suppressor Activity of Profilin Requires a Functional Actin Binding SiteMolecular Biology of the Cell, 2004
- Integrating Histology and Imaging Mass SpectrometryAnalytical Chemistry, 2004
- Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometryProteomics, 2003
- Direct tissue analysis using matrix‐assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparationJournal of Mass Spectrometry, 2003
- A Genomic and Proteomic Analysis of Activation of the Human Neutrophil by Lipopolysaccharide and Its Mediation by p38 Mitogen-activated Protein KinaseJournal of Biological Chemistry, 2002
- Identification of Novel TGF-β/Smad Gene Targets in Dermal Fibroblasts using a Combined cDNA Microarray/Promoter Transactivation ApproachJournal of Biological Chemistry, 2001