Methadone Treatment: Program Evaluation and Dose Response Relationships

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Abstract
Data from a heterogeneous group of 155 clients in a Methadone Treatment Program were analyzed for number of possible methadone administrations since S [the subject] joined the program, actual number of methadone administrations received, spottiness, and presence of illicit drugs [heroin] in urine analysis reports. Data were evaluated for 3 separate time spans which corresponded with 3 programmatic changes. Initially high blockading doses of methadone are effective in reducing illicit drug use, but as length of time in program increases, the efficacy of low doses of methadone in reducing illicit drug use increases. At least 1 programmatic change, a more stringent selection procedure, was demonstrated to be highly successful in reducing illicit drug use.

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