Stereodivergent Synthesis of Enantiopurecis- andtrans-3-Ethyl-4-piperidineacetates
- 11 July 2002
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (16) , 2787-2790
- https://doi.org/10.1021/ol0263245
Abstract
[reaction: see text] Starting from a common chiral bicyclic lactam 11, enantiopure trans- or cis-3-ethyl-4-piperidineacetate derivatives are obtained by conjugate addition of an enolate or a cuprate to the unsaturated lactams 12 or 18, respectively.Keywords
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