A Portal Blood Factor as the Humoral Agent in Liver Regeneration
- 12 February 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 171 (3971) , 575-577
- https://doi.org/10.1126/science.171.3971.575
Abstract
It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant. While intact livers of normal rats incorporated [methyl- 3 H]thymidine in proportion to the amount of liver removed in the partner, the greatest response occurred after a total hepatectomy. Evidence from portacaval-shunted, partially hepatectomized animals connected to normal members indicates that the factor is in portal blood and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present.Keywords
This publication has 3 references indexed in Scilit:
- Regeneration of Rat Liver: Transfer of Humoral Agent by Cross CirculationScience, 1967
- PHOSPHORUS COMPOUNDS IN ANIMAL TISSUESJournal of Biological Chemistry, 1945
- REMOVAL OF THE IMPURITIES, NUCLEIC ACID AND POLYSACCHARIDE, FROM TUBERCULIN PROTEINPublished by Elsevier ,1940