The Chromosomes in a Child with Mongolism and Acute Leukemia

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Abstract
THE association of mongolism with leukemia was firmly established by Stewart and her colleagues1 in 1958 from their survey of neoplastic disease in childhood. They found mongolism in 17 of 677 cases of leukemia and in only 1 among 739 cases of cancer. This association had been suggested before, particularly by Ingalls2 in 1947 and then by Krivit and Good,3 by Merritt and Harris4 and by Carter,5 all in 1956, as well as in a number of other case reports.6 7 8 9 10 Several authors had speculated on the nature of the association, but the theories of the etiology of mongolism then current . . .