Epidermal carcinogenicity of bis(2,3-epoxycyclopentyl)ether, 2,2-bis(p-glycidyloxyphenyl)propane, and m-phenylenediamine in C3H and C57BL/6 inbred male and female mice

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Abstract
Application of bis(2,3-epoxycyclopentyl)ether(I), 2,2-bis(p-glycidyloxyphenyl)propane (II), or a 1:1 mixture of I and II three times weekly for 24 months induced malignant epidermal tumors in C3H and C57BL/6 mice. C57BL/6 mice were more sensitive to skin carcinogenesis as evidenced by a higher frequency of mice responding at the highest doses were, for C3H: compound I, 5/80 (6 percent); II, 0/80; I + II, 51/80 (64 percent); and for C57BL/6: compound I, 5/39 (13 percent); II, 8/40 (20 percent); I + II, 32/40 (80 percent). The substantial difference in the potency of the materials applied as a 1:1 mixture as opposed to their effects when tested individually suggested synergistic interaction. Similar tests of the skin carcinogenicity of m-phenylenediamine were negative at all doses and in both strains. An increased incidence of lung tumors (p less than 0.004) relative to vehicle control was detected in C3H mice treated at the highest dose of I.

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