EFFECT OF CATION IONOPHORES ON INTRAOCULAR-PRESSURE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (10) , 851-854
Abstract
The ionophores A23187 and X537A, which increase the permeability of cell membranes to Ca2+ and other divalent cations, produced significant elevation of intraocular pressure in rabbits. Topical instillation of these ionophores in concentrations of 1.0 and 0.1% were effective. Aqueous humor protein and facility of outflow were similar in ionophore-treated and control eyes. Pretreatment with indomethacin did not block the intraocular pressure rise induced by A23187. Alterations of intracellular Ca2+ might control cellular processes within the eye as in many other biological systems.

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