Inability of Simian Virus 40 To Establish Productive Infection of Lymphoblastic Cell Lines
Open Access
- 1 May 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (9) , 4917-4920
- https://doi.org/10.1128/jvi.78.9.4917-4920.2004
Abstract
Lymphoblastic cell lines were infected with simian virus 40 (SV40) and then monitored for evidence of a productive infection. No evidence of early gene expression was found 2 days following infection, as determined by assaying viral mRNAs and early antigens. Furthermore, only small amounts of virus could be detected by plaque assay 2 days after infection, and levels slowly declined until they were undetectable after a few weeks in culture. Thus, human lymphocytes are not readily infectible with SV40 and do not provide a simple model for studying interactions of SV40 with a human cell type.Keywords
This publication has 22 references indexed in Scilit:
- Simian Virus 40 Infection of HumansJournal of Virology, 2003
- Simian Virus 40 Sequences in Human Lymphoblastoid B-Cell LinesJournal of Virology, 2003
- SV40 and human tumours: myth, association or causality?Nature Reviews Cancer, 2002
- Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donorsCancer, 2002
- Critical Role for SV40 Small-t Antigen in Human Cell TransformationVirology, 2001
- SV40 and the pathogenesis of mesotheliomaSeminars in Cancer Biology, 2001
- Natural Simian Virus 40 Strains Are Present in Human Choroid Plexus and Ependymoma TumorsVirology, 1995
- SV40 small t deletion mutants preferentially transform mononuclear phagocytes and B lymphocytes in vivoVirology, 1992
- DNA Sequences Similar to Those of Simian Virus 40 in Ependymomas and Choroid Plexus Tumors of ChildhoodNew England Journal of Medicine, 1992
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991