Eukaryotic DNA primase abortive synthesis of oligoadenylates
- 25 March 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 280 (2) , 281-283
- https://doi.org/10.1016/0014-5793(91)80312-q
Abstract
Calf thymus DNA polymerase α-primase, human placenta DNA polymerase α-primase and human placenta DNA primase synthesized oligoriboadenylates of a preferred length of 2–10 nucleotides and multimeric oligoribonucleotides of a modal length of about 10 monomers on a poly(dT) template. The dimer and trimer were the prevalent products of the polymerization reaction. However, only the oligonucleotides from heptamers to decamers were elongated efficiently by DNA polymerase α.Keywords
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