Chromosome Patterns in Rat Hepatocytes During N-2-Fluorenylacetamide Carcinogenesis2

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Abstract
The ingestion of N-2-fluorenylacetamide (2-FAA) by male rats produced hepatic nodules considered to be lineally related to the eventual appearance of hepatomas. These hepatomas were analyzed for chromosome composition and demonstrated diploid and tetraploid populations as well as a marker, metacentric chromosome. Metaphase hepatocytes were derived from the hepatic nodules and their karyotypes analyzed. Chromosome gaps and breaks were noted as well as a relative absence of the tetraploid population seen in normal, adult livers and in tumors. Under these conditions of experimental carcinogenesis, at a time when the probability of eventual malignancy is determined in these livers, their chromosome alterations are few and difficult to correlate with the distinctive patterns of the eventual hepatomas.

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