Protective Effect of Neonatal Thymectomy on Mouse LCM Infection

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Abstract
Summary Mice thymectomized at birth were protected against the lethality of intracerebral and intraperitoneal infection with LCM virus given 3 to 4 weeks later. Although virus multiplication was not prevented, as evidenced by high infectivity titers in the brain 6 to 8 weeks after infection, the meningeal inflammatory reaction was suppressed. These observations provide further evidence for the importance of tissue hyperreactivity and lymphocytic inflammatory response in production of symptomatology.