Intra-Hyphal Hyphae in "Clock" Mutants of Neurospora

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Abstract
The "clock" (CL11A) mutant of Neurospora crassa forms abundant intra-hyphal hyphae as a result of the invasion of moribund hyphal segments by contiguous healthy cells within the same hypha. These intrahyphal hyphae can exit in the host hypha by penetrating its wall. Hyphal invasions are localized near the end of each growth cycle hi clock and appear to be an important feature of the mutation. Hyphal invasions in the early part of a growth cycle in clock and in wild N. crassa are rare.