Possible defect in xenobiotic activation before glycine conjugation in protein-energy malnutrition
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 12 (12) , 849-853
- https://doi.org/10.3109/00498258209038956
Abstract
1. [14C]Benzoic acid administered to rats fed a normal diet was excreted mainly (99% of 24h excretion) as hippuric acid. 2. In protein-energy malnourished rats, only about 74% of [14C]benzoic acid administered was excreted as hippuric acid. The remainder was excreted as the glucuronide conjugate. 3. The oxidative phosphorylation capacity of liver mitochondria of malnourished rats was 30% less than that of normal rat liver mitochondria. 4. The decreased rate in oxidative phosphorylation is discussed in relationship to the observed decrease in glycine conjugation.This publication has 17 references indexed in Scilit:
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