A novel murine cathelin‐like protein expressed in bone marrow
- 5 August 1996
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 391 (1-2) , 5-8
- https://doi.org/10.1016/0014-5793(96)00692-8
Abstract
A novel cDNA encoding a putative secreted protein was isolated from murine bone marrow. The encoded protein named MCLP ( urine athelin- ike rotein) was found to be highly homologous to the pig cathelin, and to four neutrophil antimicrobial polypeptides: CAP 18, indolicidin, Bac 5 and FALL-39. Secondary structure prediction studies identified a highly cationic region in the C-terminal part of prepro-MCLP with a tendency to adopt an amphipathic α-helical conformation, as observed in many antimicrobial peptides. However, no antibacterial activity was observed with the synthetic peptide corresponding to this region of MCLP.
Keywords
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