Long‐term Effect of Clofibrate on Albumin Turnover and Distribution in Man

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Abstract
The long-term effect of clofibrate (at least 6 mo. treatment) on albumin metabolism was investigated in 7 subjects and the results were compared with those from 15 control subjects. Human albumin labeled with 131I was used as a tracer. A significant difference between the groups was found in the following parameters. The clofibrate-treated group had a prolonged rapid component (t1 1/2) of the disappearance curve (P < 0.05), relatively increased albumin in the extravascular space (i.e., decreased distribution ratio, P < 0.01) and increased extravascular albumin space when corrected for body size by calculating it as per cent of the extravascular bromide space (P < 0.01). There was no significant difference between the groups in albumin synthesis, fractional catabolic rate or the slow component (t2 1/2) of the disappearance curve. Long-term treatment with clofibrate may cause changes in the intercellular matrix.