Catalytic Activity of Isoborneol-Derived Sulfides in Asymmetric Addition of Diethylzinc to Benzaldehyde.
- 1 January 1995
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 43 (12) , 2243-2245
- https://doi.org/10.1248/cpb.43.2243
Abstract
Enantioselective addition of diethylzinc to benzaldehyde in the presence of easily available, β-hydroxysulfides 1 was investigated. The use of a catalytic amount of 1 gave (S)-1-phenylpropanol in excellent yield with high enantioselectivity, ranging from 85 to 88% ee.Keywords
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