Reversible limbic encephalitis with antibodies against the membranes of neurones of the hippocampus

Abstract
A 30-year-old woman was admitted to our hospital (Jichi Medical University, Tochigi, Japan) in April 2004 because of headache, fever and disorientation for 3 days. Figure 1A summarises the clinical course of the patient. She had no relevant family or medical history of interest. Her temperature was 37.8°C. Neurological examination on admission showed only recent memory disturbance. Examination of CSF showed increased protein concentration (670 mg/l), an increased number of mononuclear-dominant cells (40/mm3) and 67 mg/dl glucose. CSF cytology was negative for malignant cells. Polymerase chain reaction for herpes simplex virus (HSV) was negative. No marked increase in anti-HSV, varicella zoster virus, human herpes virus type …