Variations in the Release of the NH2-Terminal Fragment of Gastrin-17 in the Course of Duodenal Ulcer Disease

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Abstract
Fasting and meal-stimulated NH2-terminal gastrin concentrations in serum were significantly higher in patients with active duodenal ulcer than in control subjects and in patients with inactive duodenal ulcer (p 2-and COOH-terminal gastrin concentrations occurred both during meal stimulation and as response to adrenalin or secretin infusion. In a longitudinal study of duodenal ulcer patients, higher NH2-than COOH-terminal gastrin concentrations were associated with the active phase of the disease, whereas this seldom occurred during the inactive phase (p 2-terminal fragment of gastrin-17 are released to the circulation during the active phase of duodenal ulcer.