Hepatic and extrahepatic triglyceride lipase activity in uraemic patients on chronic haemodialysis

Publisher Website
Google Scholar
Abstract
In 11 patients with chronic renal insufficiency treated by intermittent hemodialysis and in 10 normal subjects, hepatic and extrahepatic triglyceride lipase activity of post heparin plasma was selectively measured, utilizing the different sensitivity of both enzymes to inhibition by protamine sulfate. In uremic patients, hepatic triglyceride lipase activity was significantly decreased and extrahepatic triglyceride lipase activity was normal when compared with the control group. The uremic subjects showed a moderate hypertriglyceridemia; their serum cholesterol level was normal. The high triglyceride concentration was due to an increase of very low density lipoproteins and low density lipoproteins of the density between 1.006 and 1.019 g/ml (LDL1). The concentration of low density lipoproteins of the density between 1.019 and 1.063 g/ml (LDL2) was decreased. LDL2 were relatively rich in triglycerides when compared with LDL2 from the control group.