Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms
Top Cited Papers
- 1 August 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 3 (8) , 601-614
- https://doi.org/10.1038/nrc1144
Abstract
Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.Keywords
This publication has 107 references indexed in Scilit:
- Hypomethylation of ras oncogenes in primary human cancersPublished by Elsevier ,2005
- Calcium signalling: dynamics, homeostasis and remodellingNature Reviews Molecular Cell Biology, 2003
- Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control studyGastroenterology, 2003
- Protein Kinase C (PKC) Phosphorylation of the Ca2+-sensing Receptor (CaR) Modulates Functional Interaction of G Proteins with the CaR Cytoplasmic TailPublished by Elsevier ,2002
- Ca2+-stimulated Ca2+ Oscillations Produced by the Ca2+-sensing Receptor Require Negative Feedback by Protein Kinase CPublished by Elsevier ,2002
- A specific binding protein/receptor for 1α,25-dihydroxyvitamin D3 is present in an intestinal caveolae membrane fractionBiochemical and Biophysical Research Communications, 2002
- Intake of dietary folate vitamers and risk of colorectal carcinomaCancer, 2002
- DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsNature, 2002
- Protein kinase C α modulates growth and differentiation in Caco-2 cellsGastroenterology, 1998
- Extracellular Cation Sensing by the Enterocyte: Prediction of a Novel Divalent Cation "Receptor"Biochemical and Biophysical Research Communications, 1995