Aromatization of Androstenedione and Testosterone by Rhesus Monkey Hypothalamus and Limbic System

1 January 1973

journal article
Published by S. Karger AG in Neuroendocrinology

Vol. 11 (3) , 177-182
https://doi.org/10.1159/000122130

Abstract

Double labeled in vitro incubation studies using ¹⁴C-androstenedione and ³H-testosterone have demonstrated aromatizing activity in the rhesus monkey hypothalamus and limbic system, predominantly in the former tissue. Under these conditions, no interconversion was shown between androstenedione and testosterone or estrone and estradiol. Androstenedione conversion to estrone (1.0–10.0 × 10^–3%) was greater than that of testosterone to estradiol (0.2–3.6 × 10^–3%), especially in the limbic system. No aromatization was demonstrated in pituitaries or cerebral cortex from these animals.

Keywords

BRAIN AROMATIZATION
RHESUS MONKEY
HYPOTHALAMUS
LIMBIC SYSTEM
ANDROSTENEDIONE
TESTOSTERONE
ESTRONE
ESTRADIOL

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