Thrombin signalling and protease-activated receptors
Top Cited Papers
- 1 September 2000
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 407 (6801) , 258-264
- https://doi.org/10.1038/35025229
Abstract
How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.Keywords
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