ASSIGNMENT OF THE HUMAN PRO-ALPHA-2(I) COLLAGEN STRUCTURAL GENE (COLIA2) TO CHROMOSOME-7 BY MOLECULAR HYBRIDIZATION
- 1 January 1982
- journal article
- research article
- Vol. 34 (3) , 381-387
Abstract
A c[complementary]DNA for the pro.alpha.2 chain of human type I collagen was recently cloned and amplified. This specific probe was used to identify the human chromosome carrying the pro.alpha.2(I) collagen gene. The DNA from 17 independent human/hamster and human/mouse somatic cell hybrids was digested by Eco RI and the restriction pattern analyzed in Southern blot experiments, using the 32P-labeled cDNA as a hybridization probe. The gene coding for the pro.alpha.2 collagen subunit could be unambiguously assigned to human chromosome 7. All the other chromosomes, including chromosome 17, were excluded.This publication has 21 references indexed in Scilit:
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