Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Top Cited Papers
- 20 September 2010
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 11 (10) , 889-896
- https://doi.org/10.1038/ni.1937
Abstract
Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.Keywords
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