Regulatable production of mature insulin from a hepatocyte cell line: insulin production is up-regulated by cAMP and glucocorticoids, and down-regulated by insulin

This publication has 20 references indexed in Scilit:

• Proinsulin cleaved by furin is processed to chromatographically mature insulin by carboxypeptidases in nonneuroendocrine cells
  Peptides, 1996
• Synthesis and Processing of Genetically Modified Human Proinsulin by Rat Myoblast Primary Cultures
  Human Gene Therapy, 1996
• Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non‐endocrine cell line, COS‐7
  FEBS Letters, 1992
• Cellular Engineering for the Treatment of Metabolic Disorders: Prospects for Therapy in Diabetes
  Nature Biotechnology, 1992
• Metabolic control of gene expression: in vivo studies with transgenic mice
  Trends in Biochemical Sciences, 1992
• Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on Transcription
  Science, 1990
• Transfection of hepatic genes into adult rat hepoatocytes in primary culture and their tissue‐specific expression
  European Journal of Biochemistry, 1989
• Regulation of Insulin-Gene Expression
  New England Journal of Medicine, 1987
• Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles
  Cell, 1987
• Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation
  Cell, 1983