Some Effects of DDT on Reproduction in Mice

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Abstract
Adult laboratory mice (Mus musculus) fed diets of chick starter mash containing 100 to 300 ppm of DDT [1,1,1-tricliloro-2,2-bis (p-chlorophenyl)-ethane] were able to survive for extended periods. However, breeding tests showed that the fertility of the mice declined following exposure to increased concentrations of DDT. Groups of mice exposed to levels of 200 and 300 ppm of DDT in the diet produced the same number of young per litter as the controls, but the number of females that produced no young was significantly greater in the group fed 300 ppm of DDT in the diet. It is concluded that reproductive failures in mice can occur following exposure to sublethal quantities of DDT.