THE REFRACTORY STATE PRODUCED BY ADRENAL EXTRACT1¹
- 1 February 1939
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 24 (2) , 197-201
- https://doi.org/10.1210/endo-24-2-197
Abstract
A study was made of conditions necessary for the development of the refractory state from adrenal extracts in dogs, cats and a pig. All animals were kept on constant regime including diet. Subcut. injs. failed to produce the refractory state even after many injs. over a long period of time (in 3 dogs). There was no indication that the refractory state from intraven. inj. was due to haptene formation. An unquestionable refractory state was produced (in 1 cat and 1 dog) by intraperitoneal injs. The refractory state is sp. specific. This was shown by expts. on 4 dogs. The pig (a very young animal) failed to develop the refractory state to either pig or beef adrenal extract.This publication has 1 reference indexed in Scilit: