New Prodrugs of Aciclovir with Antiviral Activity
- 1 January 1991
- journal article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (1-3) , 279-282
- https://doi.org/10.1080/07328319108046459
Abstract
A series of 0-alkoxyalkyl ethers of aciclovir (ACV) have been synthesized in the reaction of 9-[2-hydroxyethoxymethy1]-N2-acetylgua-nine and its 8-bromo derivative with a-vinylethers. The compounds are characterized by much higher solubility as compared with ACV and display very good antiviral activity against HSV-1 in mice.Keywords
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