PHENOMENON OF RESTRICTION OF BACTERIOPHAGE-T4 AMBER-SUPPRESSOR

  • 1 January 1975
    • journal article
    • research article
    • Vol. 11  (6) , 114-118
Abstract
The action of a bacteriophage suppressor can be restricted due to mutations arising in the genome of the host bacteria. Bacterial strains Escherichia coli BN and CAN were isolated in which a complete restriction of the action of phage suppressor psu+ took place. In these strains the restriction of serin-specific phage suppressors psua+ and psub+ occurs. The action of bacteriophage suppressor su3+ contained in E. coli CAN is not abolished in this strain. The abolishment of the action of glutamine-specific phage suppressor in both strains is not realized. In E. coli BN and CAN, the restriction of action of only definite tRNA type takes place. Mutation alterations in the bacterial strains obtained can be due to the change of ribosomes, amioacyl-tRNA-synthetase or suppressor tRNA. In this case, the possibility of mutation alterations in the gene controlling the synthesis of suppressor tRNA is excluded, but there is a possibility of changing the tRNA molecule itself during its maturation.

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