Effect of individual amino acid supplements on the toxicity of excess tyrosine in rats.

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Abstract
The effects of individual amino acid supplements on the development of tyrosine toxicity in growing rats fed 10% casein containing 5% tyrosine were studied. Each amino acid was added at levels equivalent to its content in 20% casein. Addition of methionine to the high tyrosine diet partially alleviated both growth depression and pathological lesions. Threonine and cystine had a somewhat beneficial effect, but the single addition of other amino acids was not effective. Some amino acids enhanced the severity of the toxicity. The effects of methionine supplementation were highest at 0.66-1.32% levels (equivalent to the methionine content in 20-40% casein). By supplementing both 0.66% methionine and 0.90% threonine to the high tyrosine diet, growth was significantly improved and toxic lesions were completely prevented. The preventative effects caused by the extra addition of protein (casein) to rats fed a high tyrosine-low protein diet were mainly attributed to the effectiveness of the methionine and threonine contained in it.

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