CYCLOSPORIN A AS A MEANS OF PREVENTING REJECTION OF SKELETAL MUSCLE ALLOGRAFTS IN MICE
- 1 April 1981
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 31 (4) , 266-271
- https://doi.org/10.1097/00007890-198104000-00007
Abstract
Isografts and allografts of skeletal muscle inserted into the limbs of mice initially degenerate. After 5-8 days newly formed myotubes appear in the graft which develop into mature muscle fibers. In nontolerant hosts allografts are rejected between the 10th and 12th days. In mice treated with cyclosporin A, this effect persists for 12 days after the end of treatment. Isoenzyme marker studies indicate that the regenerated graft is composed of host and donor tissue. Donor isoenzyme does not persist when grafts are rejected.This publication has 8 references indexed in Scilit:
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