Neurohistology of two mammalian mutations

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Abstract
Two mammalian mutations, the wabbler-lethal mouse and the ataxic rabbit, show motor disturbances coupled with myelin disturbances. The mouse defect appears to be developmental and associated with pathology of inter-fascicular glia and faulty myelin formation or maintenance. The rabbit defect is degenerative and associated with breakdown of axis cylinders and preterminals, as well as of myelin sheaths. The mouse and rabbit conditions bear strong resemblances, respectively, to leukodystrophy and system degeneration in humans.

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