Tryptic Peptides obtained from Gelatins derived from Normal and Rheumatoid Arthritic Collagens

Open Access
Publisher Website
Google Scholar
Abstract
Gelatins were prepared from purified collagens obtained from normal tendon and rheumatoid arthritic synovial tissues, and the tryptic digestion products of these gelatins were compared by finger-printing analysis. A close structural similarity was observed. Two peptides were present in normal gelatin which appeared to be entirely absent from (or present in only trace amounts in) the three rheumatoid gelatins so far examined. The usefulness of this type of analysis has been demonstrated for the structural study of pathological collagens.