EFFECTS OF IMMUNOMODULATION WITH INTERFERON-± ON HEPATIC ISCHEMIA-REPERFUSION INJURY

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Abstract
The development of an inflammatory response after injury depends on the participation of a variety of cell populations and endogenous mediators, lnterferon-± (IFN-±) is a potent cellular immunomodulating cytokine that contributes to acute and chronic inflammation. In this study, the effects of immunomodulation on ischemia-reperfusion injury were examined using increasing doses of recombinant, rabbit-specific IFN-± in an in situ model of hepatic ischemia-reperfusion. Pretreatment with low dose IFN-± augmented injury as measured by histology, aminotransferase concentrations, and myeloperoxidase activity. By contrast, high dose IFN-± pretreatment, equivalent to IFN-± supplements used in clinical trials, resulted in a lack of neutrophil infiltration and minimal progression of late phase, neutrophil-mediated reperfusion injury. These results suggest that immunomodulating mediators such as IFN-± may play a regulating role in the evolution of ischemia-reperfusion, contributing to the development and resolution of acute hepatic injury.

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