Treatment of Cancer of the Head and Neck by Chemotherapy

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Abstract
THE OF chemotherapeutic agents as adjuvants in palliative treatment for malignant tumors in other parts of the body suggested that perhaps beneficial effects could be obtained in lesions involving the head and neck. Although the specificity of these various compounds for certain types of cancer has already been demonstrated in leukemia, lymphoma, and certain epithelial tumors, the variable response of the more common forms of cancer to these agents does not necessarily rule out their use as a last resort. The amenability of tumors in regions of the head and neck to treatment with chemotherapeutic drugs by perfusion and infusion is determined to some extent by the source of the blood supply of the tumors. The blood must be almost entirely supplied by the external carotid artery or its branches. The initial reports on the use of chemotherapeutic drugs for inoperable cancer of the head and neck as a palliative

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