Effect of polyamines on the proliferative response of T cells stimulated with antigen
- 1 December 1975
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 5 (12) , 844-849
- https://doi.org/10.1002/eji.1830051209
Abstract
Presence of polyamines in cultures of human lymphocytes amplifies the proliferative response of sensitized T cells to antigens in vitro. Similar effects of aminoguanidine, an inhibitor of diamine oxydase, suggests a role of endogenous polyamines in normal proliferative events. This effect may have practical application in the amplification of low in vitro responses to antigens and in mixed lymphocyte cultures.Keywords
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