Gastrin derivatives investigated for secretory potency and for changes in gastric mucosal histamine formation
Open Access
- 1 March 1970
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 38 (3) , 473-477
- https://doi.org/10.1111/j.1476-5381.1970.tb10589.x
Abstract
1 . Acid secretion and rate of histamine formation in the gastric mucosa were determined in rats after injection of hog gastrin II, gastrin pentapeptide and some substituted analogues of the C-terminal tetrapeptide of gastrin. 2 . Accelerated mucosal histamine formation was induced by hog gastrin II, gastrin pentapeptide and those analogues which elicited acid secretion, whereas secretorily inactive derivatives did not alter histamine formation.Keywords
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