Epoxide-diol pathway of Δ1-THC in the ratin vitro
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 10 (11) , 805-809
- https://doi.org/10.3109/00498258009033810
Abstract
1. 1α,2α-Epoxyhexahydrocannabinol was identified as a metabolite of Δ1-tetrahydrocannabinol. 2. The two trans-1,2-dihydroxyhexahydrocannabinol isomers, 1α,2β-dihydroxy-hexahydrocannabinol and 1β,2α-dihydroxyhexahydrocannabinol (as their acetates) were tentatively identified as metabolites from incubation of 1α,2α-epoxyhexahydrocannabinol with rat hepatic microsomes in vitro. 3. The 1α,2α-epoxyhexahydrocannabinol acetate was found to be a good substrate for epoxide hydratase as compared to styrene oxide. 4. The synthesis of metabolites of 1α,2α-epoxyhexahydrocannabinol is described.This publication has 15 references indexed in Scilit:
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