Hygromycin A and Methoxyhygromycin, Novel Inhibitors of K88 Antigen Synthesis of EnterotoxicEscherichia coli Strain

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Abstract
During the screening for inhibitors of K 88 antigen synthesis that suppress hemagglutination by E. coli E68 NIH 457-71, we found Streptomyces sp. No. 207 produced two active substances, one of which was identified as hygromycin A. Another new compound, named methoxyhygromycin, was very similar to hygromycin A but methoxyhygromycin had a methoxy group on the neoinosamine-2 moiety instead of the methylene dioxy group found in hygromycin A. Although hygromycin A and methoxyhygromycin had almost no effect on the growth of E. coli E68 NIH 457-71, they inactivated the hemagglutination activity of E. coli at low concentrations of 12.5μg/ml and 25μg/ml, respectively.